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Wolfgang M. Schuehly

Natural Product Chemist


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1. Frei, B., Heinrich, M., Bork, P.M., Herrmann, D., Jaki, B., Kato, T., Kuhnt, M., Schmitt, J., Schühly, W., Volken, C. and Sticher, O. Multiple Screening of Medicinal Plants from Oaxaca, Mexico: Ethnobotany and Bioassays as a Basis for Phytochemical Investigation. Phytomed. 5, 177-186 (1998). [Pubmed]

2. Schühly, W., Heilmann, J., Çalis, I. and Sticher, O. New Triterpenoids with Antibacterial Activity from Zizyphus joazeiro. Planta Med. 65, 740-743 (1999). [Pubmed]

3. Schühly, W., Heilmann, J., Çalis, I. and Sticher, O. Novel Triterpene Saponins from Zizyphus joazeiro. Helv. Chim. Acta 83, 1509-1516 (2000). [Pubmed]

4. Heilmann, J., Çalis, I., Kirmizibekmez, H., Schühly, W., Harput, S. and Sticher, O. Radical Scavenger Activity of Phenylethanoid Glycosides in FMLP Stimulated Human Polymorphonuclear Leukocytes – Structure Activity Relationships. Planta Med. 66, 746-748 (2000). [Pubmed]

5. Schühly, W., Khan, I. and Fischer, N.H. The Ethnomedicinal Use of Magnoliaceae from the Southeastern United States as Leads in Drug Discovery. Pharm. Biol. 39, 63-69 (2001). [Pubmed]

6. Ersöz, T., Schühly, W., Popov, S., Nedjalka, H. and Sticher, O. Iridoid and phenylethanoid glycosides from Phlomis longifolia var. longifolia. Nat. Prod. Lett. 15, 345-351 (2001). [Pubmed]

7. Feltenstein, M.W., Schühly, W., Warnick, J.E., Fischer, N.H. and Sufka, K.J. Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear´s Foot. Pharm. Biochem. & Behaviour 79, 399-402 (2004). [Pubmed]

8. Crockett, C., Schühly, W., Belaj, F. and Khan, I.A. Hyperolactone C. Acta Cryst. Sect. E Structure Reports Online E60, o2174-o2176 (2005). [Abstract]

9. Schühly, W., Crockett, S. and Fabian, W. Hyperolactone C: Determination of Its Absolute Configuration by Comparison of Experimental and Calculated CD Spectra. Chirality 17, 250-56 (2005). [Pubmed]

10. Wenzig, E., Kunert, O., Ferreira, D., Schmid, M., Schühly, W., Bauer, R. and Hiermann A. Flavonolignans from Avena sativa. J. Nat. Prod. 68, 289-92 (2005). [Pubmed]

11. Frankfater, C., Schühly, W., Fronczek, F.R. and Slattery, M. Processing of a sesquiterpene lactone by Papilio glaucus caterpillars. J. of Chem. Ecol. 31, 2541-50 (2005). [Pubmed]

12. Ojwang, J.O., Wang, Y-H., Wyde, P.R., Fischer, N.H., Schühly, W., Appleman, J.R., Hinds, S. and Shimasaki, C.D. A novel inhibitor of respiratory syncytial virus isolated from ethnobotanicals. Antiviral Research 68, 163-172 (2006). [Science Direct]

13. Kunert, O., Adavi Rao, B.V., Babu, G.S., Padmavathi, M., Kumar, B.R., Alex, R.M., Schühly, W., Simic, N., Kühnelt, D. and Appa Rao, A.V.N. Novel Steroidal Glycosides from two Indian Caralluma species, C. stalagmifera and C. indica. Helv. Chim. Acta 89, 201-209 (2006). [Wiley Online]

14. Swamy, R.C., Kunert, O., Schühly, W., Bucar, F., Ferreira, D., Rani, V.S., Kumar, B.R. and Appa Rao, A.V.N. Structurally Unique Biflavonoids from Selaginella chrysocaulos and Selaginella bryopteris. Chem. & Biodiv. 3, 405-413 (2006). [Pubmed]

15. Crockett, S., Schühly, W. and Bauer, R. Plant Antiemetics. Pharmazie in unserer Zeit 36, 381-388 (2007). [Pubmed]

16. Ma, G., Khan, S.I., Benavides, G., Schühly, W., Fischer, N.H., Khan, I.A. and Pasco, D.S. Inhibition of NF-kB-mediated transcription and induction of apoptosis by melampolides and repandolides. Cancer Chemother. Pharmacol. 60, 35-43 (2007). [Pubmed]

17. Schühly, W., Fabian, C., Jahangir, S. and Fabian W.M.F. Structure and absolute configuration of loliolide isomers determined by comparison of calculated and experimental CD spectra. Proceedings of the International Electronic Conference on Synthetic Organic Chemistry. Nov. 11th, 1-30 (2007). [Fulltext]

18. Tatli, I.I., Schühly, W. and Akdemir, Z.S. Secondary metabolites from bioactive methanolic extract of Verbascum pycnostachyum Boiss. & Helder flowers. Hacettepe Universitesi Eczacilik Fakultesi Dergisi 27, 23-32 (2007). [Fulltext]

19. Kunert, O., Swamy, R.C., Kaiser, M., Presser,A., Buzzi,S., Appa Rao, A.V.N. and Schühly, W. Antiplasmodial and Leishmanicidal Activity of Biflavonoids from Indian Selaginella bryopteris. Phytochemistry Lett. 1, 171-74 (2008). [Science Direct]

20. Schühly, W., Ross, S.A., Mehmedic, Z. and Fischer, N.H. Essential Oil Analysis of the Follicles of Four North American Magnolia Species. Nat. Prod. Comm. 7, 1117-1119 (2008).

21. Tatli, I.I., Schühly, W., Kunert, O., Bedir, E. and Akdemir, Z.S. Secondary metabolites from the aerial parts of Verbascum dudleyanum and their biological activities. Chemistry of Natural Compounds. 44, 292-95 (2008). [Springer]

22. Schühly, W. Magnolia - Eine im Westen bislang als Heilpflanze wenig beachtete Pflanzengattung. Phytotherapie Austria 2, 8-10 (2008).

23. Kunert, O, Rao, V.G., Babu, G.S., Sujatha, P., Sivagamy, M., Anuradha, S., Rao, B.V.A., Kumar, B.R., Alex, R.M., Schühly, W., Kühnelt, D., Rao, G.V., Appa Rao, A.V.N. Pregnane glycosides from Caralluma adscendens var. fimbriata. Chem. & Biodiv. 5, 239-250 (2008). [Pubmed]

24. Gachet, M.S. and Schühly, W. Jacaranda – An ethnopharmacological and phytochemical review. J. of Ethnopharm. 121, 14-27 (2009). [Pubmed]

25. Teppner, H., Schühly, W. and Weakley, A.S. The chromosome numbers of Waldsteinia (Rosaceae-Colurieae) in North America. Phyton Annales Rei Botanicae 48, 225-238 (2009). [Pubmed]

26. Schühly, W., Khan, S.I., and Fischer, N.H. Neolignans from North American Magnolia Species with Cyclooxygenase 2 Inhibitory Activity. Inflammopharmacology 17, 106-110 (2009). [Pubmed]

27. Schühly, W., Skarbina, J., Kunert, O., Nandi, O.I. and Bauer, R. Chemical characterization of Magnolia biondii (Flos Magnoliae, Xin Yi). Nat. Prod. Comm. 4, 231-234 (2009). [Pubmed]

28. Schühly, W., Hüfner, A., Pferschy-Wenzig, E.M., Prettner, E., Adams, M., Bodensieck, A., Kunert, O., Oluwemimo, A., Haslinger, E. and Bauer, R. Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. Bioorg. Med. Chem. 17, 4459-4465 (2009). [Pubmed]

29. Kunert, O., Sreekanth, G., Babu, G.S., Adavi Rao, B.V.R., Radhakishan, M., Ravi Kumar, B., Saf, R., Appa Rao, A.V.N. and Schühly, W. Cycloartane triterpenes from dikamali, the gum resin of Gardenia gummifera and G. lucida. Chem. & Biodiv. 6, 1185-1192 (2009). [Pubmed]

30. Crockett, S., Eberhardt, M., Kunert, O. and Schühly, W. Hypericum species in the Páramos of Central and South America: A special focus on H. irazuense Kuntze ex N. Robson. Phytochem. Rev. 9, 255-269 (2010). [Pubmed]

31. Gachet, M.S., Lecaro, J.S., Kaiser, M., Brun, R., Navarrete, H., Muñoz, R.A., Bauer, R. and Schühly, W. Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. J. of Ethnopharm. 128, 184-197 (2010). [Pubmed]

32. Bodensieck, A., Fabian, W., Kunert, O., Belaj, F., Jahangir, S., Schühly, W. and Bauer, R. Absolute configuration of eremophilane sesquiterpenes from Petasites hybridus: Comparison of experimental and calculated CD spectra. Chirality 22, 308-319 (2010). [Pubmed]

33. Blunder, M., Pferschy-Wenzig, E.M., Fabian, W.M.F., Hüfner, A., Kunert, O., Saf, R., Schühly, W. and Bauer, R. Derivatives of schisandrin with increased inhibitory potential on prostaglandin PGE2 and leukotriene B4 formation in vitro. Bioorg. Med. Chem. 18, 2809-2815 (2010). [Pubmed]

34. Gachet, M.S., Kunert, O., Kaiser, M., Brun, R., Muñoz, R.A. and Bauer, R. and Schühly, W. Jacaranone-Derived Glucosidic Esters from Jacaranda glabra and their Activity against Plasmodium falciparum. J. Nat. Prod. 73, 553-556 (2010). [Pubmed]

35. Schühly, W., Gröblacher, B., Neyer, J., Fronczek, F., Fabian, W.M.F. and Kunert, O. Dibenzocyclooctadiene lignans from Magnolia and Talauma (Magnoliaceae): their absolute configuration ascertained by circular dichorism and X-ray crystallography and re-evaluation of previously published pyramidatin structures. Phytochemistry 71, 1787-1795 (2010). [Pubmed]

36. Schuehly, W., Voith, W., Teppner, H. and Kunert, O. Substituted Dineolignans from Magnolia garrettii. J. Nat. Prod. 73, 1381-1384 (2010). [Pubmed]

37. Zovko Koncic, M., Kremer, D., Schühly, W., Brantner, A., Karlovic, K., Kalodera, Z. Chemical Differentiation of Berberis croatica and B. vulgaris Using HPLC Fingerprinting. Croatica Chem. Acta 83, 451-456 (2010). [Fulltext]

38. Böhmdorfer, M., Maier-Salamon, A., Taferner, B., Reznicek, G., Thalhammer, T., Hering, S., Hüfner, A., Schuehly, W. and Jäger, W. In vitro Metabolism and Disposition of Honokiol in Rat and Human Livers. J. Pharm. Sci. 100, 3506-3516 (2011). [Pubmed]

39. Gachet, M.S., Kunert, O., Kaiser, M., Brun, R., Zehl, M., Keller, W., Muñoz, R.A., Bauer, R. and Schuehly, W. Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. J. Nat. Prod. 74, 559-566 (2011). [Pubmed]

40. Taferner, B., Schuehly, W., Huefner, A., Baburin, I., Wiesner, K., Ecker, G.F. and Hering, S. Modulation of GABAA-Receptors by Honokiol and Derivatives: Subtype Specificity and Structure-Activity Relationship. J. Med. Chem. 54, 5349-5361 (2011). [ACS]

41. Schuehly, W., Viveros Paredes, J. M., Kleyer, J., Huefner, A., Anavi-Goffer, S., Raduner, S., Altmann, K.-H. and Gertsch, J. Mechanisms of osteoclastogenesis inhibition by a new class of biphenyl-type cannabinoid CB2 receptor inverse agonists. Chem. & Biol. 18, 1053-1064 (2011). [Pubmed]

42. Schuehly, W. and Teppner, H. Magnolia garrettii at the botanic garden in Graz, Austria. – Magnolia – J. Mag. Soc. 46, (Issue 89) 36-39 (2011). [Fulltext]

43. Liu, N.Q., Schuehly, W., von Freyhold, M. and van der Kooy, F. A novel purification method of artemisinin from Artemisia annua. – Ind. Crops & Prod. 34, 1084-1088 (2011). [Science Direct]

44. Kretschmer, N., Blunder, M., Kunert, O., Rechberger, G.N., Bauer, R. and Schuehly, W. Cytotoxic Furanogermactranolides from the Flowers of Helianthus angustifolius. Planta Med. 77, 1912-1915 (2011). [Fulltext]

45. Chizzali, C., Khalil, M.N.A., Beuerle, T., Schuehly, W., Richter, K., Flachowsky, H., Peil, A., Hanke, M.-V., Liu, B. and Beerhues, L. Formation of biphenyl and dibenzofuran phytoalexins in the transition zones of fire blight-infected stems of Malus domestica cv. ‘Holsteiner Cos’ and Pyrus communis cv. ‘Conference’. Phytochemistry 73, DOI (2012). [Pubmed]

Oral Presentations at a Scientific Congress

1. Schühly W. Chemical Analysis of Magnolia Species from the Southeastern United States, 2001 Interim Meeting of the American Society of Pharmacognosy & Council for Responsible Nutrition. Asilomar, California, U.S.A., Nov. 8 - 11, 2001.

2. Schühly W. Constituents of North American Magnolia Species: Structure, Chemistry and Biological Activities, PSNA Meeting, July 20-24, Mérida, Mexico 2002.

3. Contributed X lectures at the WHO Workshop, “Strategies for Pharmacognostic Investigations on Medicinal Plants," Iran University of Medical Sciences, Tehran, Iran, Dec. 6 - 8, 2005.

4. Schühly W. Pharmacological aspects of secondary metabolites in the genus Magnolia with emphasis on biphenyl neolignans, Institute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria, July 3, 2006.

5. Schühly, W., Hüfner, A., Wenzig, E.M., Kunert, O., Haslinger, E. and Bauer, R. Investigations on the main neolignan constituent methylhonokiol of Magnolia grandiflora as a new anti-inflammatory lead compound. 55th Intern. Congress and Annual Meeting of the Society for Medicinal Plant Research, Sept. 2-6, Graz, Austria, 2007.

6. Grabner, C., Bauer, R. and Schühly, W. Separation of biphenyl-type lignans from Magnolia grandiflora by using Fast Centrifugal Partitioning Chromatography (FCPC), 9th International Symposium on Instrumental Analysis, Pécs, Hungary, June 29-July 2, 2008.

7. Schühly, W. Magnolien – von der chemischen und pharmakologischen Seite gesehen, Biocenter Linz, Linz, Austria, Apr. 23, 2009.

8. Schühly, W. Tropische Arzneipflanzen, Urania Graz, Graz, Austria, May 4, 2010.

9. Schühly, W. Chances and challenges in drug research using natural products: The contribution of secondary metabolites from Magnoliaceae. Plenary talk (invited speaker) at the international conference "Recent advances in drug discovery", Kakatiya University, Warangal (Andhra Pradesh), India, Oct. 22-24, 2010.

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